Our multidisciplinary and multidivisional team of scientists is interested in developing a fundamental understanding of marine bacterial system architecture, regulation, and dynamics for the purpose of re-engineering synthetic constructs for Navy-relevant sensing and decontamination applications. We are addressing these challenges by using a combination of genetic, functional genomic, proteomic, biochemical, physiological, mathematical, and modeling approaches. While the major focus of this group lies in partitioning the transcriptional space in the bioluminescent marine bacterium Vibrio campbellii, we are also interested in understanding and re-engineering the quorum sensing sub-system in this bacterium and extending our systems biology tools to other members of the Vibrio core group.