NRL hosts first annual Karles Invitational Conference


9/12/2011 - 127-11r
Contact: Donna McKinney, (202) 767-2541


The Naval Research Laboratory hosted the first annual Karles Invitational Conference, named in honor of Drs. Jerome and Isabella Karle, on August 15 and 16. The professional contributions of Dr. Jerome Karle, 1985 Nobel Laureate in Chemistry, and Dr. Isabella Karle, a 1993 Bower Award Laureate and 1995 recipient of the National Medal of Science, were critical in enabling the resolution of the molecular structure and function of complex macromolecules.

Drs. Isabella and Jerome Karle (seated, center of the table), Dr. John Montgomery, NRL's Director of Research, and Dr. Bhakta Rath, Associate Director of Research (standing just behind the Karles), joined by other members of the Karle family.

While fundamental in nature, the Karles' contributions continue to have a significant impact on the basic and applied physical, chemical, metallurgical, geological and biological sciences. In commemoration of the Karles' achievements and broad scientific impact, NRL initiated the annual invitational conference to convene the leading authorities and innovators from scientific disciplines that are on the verge of producing contributions with similar reach and impact. In recognizing the rapid progress of two fields that are helping the research community realize the promise of the post-genomics era, NRL selected "Microbial Systems and Synthetic Biology" as the topic for the first conference.

The completion of the first decade of research in both fields has resulted in the development of the tools and methods necessary to make global cellular measurements, integrate these data to map, model and predict cellular function, and use this systems-level understanding to guide the rational design, construction and optimization of novel genetically engineered circuits and organisms. As a result of this considerable progress, both fields now lie on the verge of combining to develop transformative bioengineered solutions for recalcitrant problems in energy and biofuel synthesis, environmental remediation, chemical and biological sensing, pharmaceutical synthesis and materials science. It is this potential that has elicited considerable interest and investment, and resulted in the prioritization of systems and synthetic biology research in academia, industry and government.

Conference Speakers
Keynote Addresses

Dr. David Honey, Director of Research of the Office of the Secretary of Defense, Department of Defense "Department of Defense Science & Technology Planning and Synthetic Biology"

Dr. Subra Suresh, Director of the National Science Foundation "Probing Human Diseases Across Disciplinary Boundaries"

Featured Speakers

Dr. Leroy Hood, Institute for Systems Biology
Dr. Bhakta Rath, Naval Research Laboratory
Dr. Hiroaki Kitano, The Systems Biology Institute
Dr. Pamela Silver, Harvard Medical School
Dr. Bernhard Palsson, University of California, San Diego
Dr. Gary Vora, Naval Research Laboratory
Dr. John Glass, J. Craig Venter Institute
Dr. Drew Endy, Stanford University
Dr. Christopher Voigt, Massachusetts Institute of Technology
Dr. Steven Benner, Foundation for Applied Molecular Evolution
Dr. John Montgomery, Naval Research Laboratory
Dr. Adam Arkin, University of California, Berkeley
Dr. Zach Serber, Amyris
Dr. Arthur Grossman, Solazyme, Carnegie Institution for Science
Dr. Andreas Schirmer, LS9, Inc.

The goal of the conference was to bring together those who are involved in systems and synthetic biology research to discuss the history, progress and recent breakthroughs in these fields. NRL conference planners also hoped that the event would provide an intimate atmosphere to promote the exchange of ideas and address current limitations and potential end user needs. The two-day program included presentations by leading authorities and innovators and represented the diversity of ideas, approaches and microbial systems used in both of these fields. At its conclusion, the conference had successfully provided a forum for approximately 150 invited multidisciplinary scientists, sponsors, policy makers, industrialists and technical society leaders to discuss the current state, challenges and future of microbial systems and synthetic biology research.

The NRL scientific committee members for this first annual conference were Dr. Gary J. Vora, Dr. Banahalli Ratna and Dr. Bhakta Rath. "As anticipated, a well-planned assemblage of key speakers and invited attendees has resulted in a number of planned research collaborations and coordinations between several academic, government, and industrial institutions," said Rath.



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The U.S. Naval Research Laboratory is the Navy's full-spectrum corporate laboratory, conducting a broadly based multidisciplinary program of scientific research and advanced technological development. The Laboratory, with a total complement of nearly 2,800 personnel, is located in southwest Washington, D.C., with other major sites at the Stennis Space Center, Miss., and Monterey, Calif. NRL has served the Navy and the nation for over 90 years and continues to meet the complex technological challenges of today's world. For more information, visit the NRL homepage or join the conversation on Twitter, Facebook, and YouTube.

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