Catalytic reactions, particularly those involving hydrolytic mechanisms, are a critical area to research in order to enable the development of new countermeasure approaches against chemical and biological weapons of mass destruction. We are interested in understanding the basis of how to enhance metal-based homogeneous or heterogenized catalysts and catalytic reactions that can be directed to either chemical agent neutralization and/or bacterial/viral decontamination. Catalysis can be finely tuned, both sterically and electronically, through a judicious selection of ligands, neutral molecules, or ions bound either covalently or electrostatically to the catalytically active metal ion center. Our project focuses on enhancing hydrolysis using a novel approach that combines electronically-modulated catalysis - via molecular wires attached to nanoparticle (NP) surfaces - with additional desolvation effects, and cooperative effects of ligand stabilized multi-metallic catalytic centers at NP surfaces.