This section emphasizes the miniaturization of analytical and bioanalytical tools for specifically meeting Navy needs. Integration of microelectronics, microlithography, analytical detection methodology, and microfluidics are combined to develop novel chemical sensing devices. Microfluidic systems and structures are designed on miniaturized microchip platforms to completely encompass a typical analytical separations laboratory, including extraction, preconcentration, injection, separation, pre- and post-column derivatization and detection techniques. Basic research understanding of the electrical double layer in microfluidic to nanofluidic systems is being developed in order to create high pressure electrokinetic pumping systems suitable for high pressure valving and actuation applications on microchips. Research is also being performed on the development of optical chromatography and the utilization of optical trapping for the separation of molecules based on both size and refractive index.

Selected Publications

2008 Borowsky, J., W. Lu, and G. E. Collins, "High Pressure Electroosmotic Pump Based on a Packed Bed Planar Microchip", Sensors and Actuators B: Chemical, vol. 131, issue 1, pp. 333-339, 2008.
2008 "Advances in Capillary Electrophoresis for Kinetic Studies", Electrophoresis, vol. 29, pp. 44-55, 2008.
2008 Newman, C. I. D., B. C. Giordano, C. L. Copper, and G. E. Collins, "Microchip MEKC Separation of Alkaloids with UV-Absorbance Spectral Detection", Electrophoresis, vol. 29, pp. 803-810, 2008.
2007 Giordano, B. C., C. I. D. Newman, P. M. Federowicz, G. E. Collins, and D. S. Burgi, "Micelle Stacking in Micellar Electrokinetic Chromatography", Analytical Chemistry, vol. 79, issue 16, pp. 6287-94, 2007.
2007 Lu, Q., P. Wu, and G. E. Collins, "Contactless conductivity detection of sodium monofluoroacetate in fruit juices on a CE microchip", Electrophoresis, vol. 28, issue 19, pp. 3485-3491, 2007.
2007 Chatrathi, M. P., J. Wang, and G. E. Collins, "Sandwich Electrochemical Immunoassay for the Detection of Staphylococcus Enterotxin B Based on Immobilized Thiolated Antibodies", Biosensors & Bioelectronics, vol. 22, issue 12, pp. 2932-2938, 2007.
2007 Collins, G. E., Q. Lu, N. Pereira, and P. Wu, "Long Pathlength, Three-Dimensional Absorbance Microchip", Talanta, vol. 72, issue 1, 2007.
2007 Hart, S. J., A. V. Terray, and J. Arnold, "Particle Separation and Collection using an Optical Chromatographic Filter", Applied Physics Letters, vol. 91, issue 17, pp. 171121-171123, 2007.
2007 Hart, S. J., A. V. Terray, J. Arnold, and T. A. Leski, "Sample Concentration Using Optical Chromatography", Optics Express, vol. 15, issue 5, pp. 2724-2731, 2007.
2006 Giordano, B. C., C. L. Copper, and G. E. Collins, "Micellar Electrokinetic Chromatography and Capillary Electrochromatography of Nitroaromatic Explosives in Seawater", Electrophoresis, vol. 27, issue 4, pp. 778-86, 2006.
2006 "Microchip Detection of Colchicines by Absorbance Detection", Analytica Chimica Acta, vol. 572, 2006.
2006 Hart, S. J., A. V. Terray, T. A. Leski, J. Arnold, and R. Stroud, "Discovery of a Significant Optical Chromatographic Difference between Spores of Bacillus anthracis and Its Close Relative, Bacillus thuringiensis", Analytical Chemistry, vol. 78, issue 9, pp. 3221-3225, 2006.
2006 Haes, A. J., A. V. Terray, and G. E. Collins, "Bead-assisted Displacement Immunoassay for Staphylococcal Enterotoxin B on a Microchip", Analytical Chemistry, vol. 78, issue 24, pp. 8412-20, 2006.
2006 Giordano, B. C., A. V. Terray, and G. E. Collins, "Microchip-Based CEC of Nitroaromatic and Nitramine Explosives using Silica-Based Sol-Gel Stationary Phases from Methyl- and Ethyl-Trimethoxysilane Precursors", Electrophoresis, vol. 27, issue 21, pp. 4295-4302, 2006.
2006 Haes, A. J., B. C. Giordano, and G. E. Collins, "Aptamer-based Detection and Quantitative Analysis of Ricin Using Affinity Probe Capillary Electrophoresis", Analytical Chemistry, vol. 78, issue 11, pp. 3758-3764, 2006.
2005 Ramsey, J. D., and G. E. Collins, "An Integrated Microfluidic Device for Solid Phase Extraction Coupled to MEKC Separation", Analytical Chemistry, vol. 77, issue 20, pp. 6664-6670, 2005.
2005 Tipple, C. A., M. Smith, and G. E. Collins, "Development of a Microfabricated Impinger for On-Chip Gas Phase Sampling", Analytica Chimica Acta, vol. 551, issue 1-2, pp. 9-14, 2005.